RMC-6272 - CAS 2382769-46-0

RMC-6272 (RM-006) is a bi-steric inhibitor that selectively targets mTORC1 with potent inhibition (>10-fold) over mTORC2. Compared to Rapamycin, RMC-6272 shows enhanced inhibition of mTORC1 and induces increased cell death in TSC2 null tumors.

MTOR, Others

PI3K/Akt/mTOR signaling, Others

2382723

C95H141FN6O27S

1850.25

[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(C[C@@H](O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCS(=O)(=O)c2ccc(C(=O)N3CCOc4ccc(cc4C3)-c3ccc(N)nc3)c(C)c2F)[C@@H](C1)OC

-20°C

Ice Packs

Small Compound