RMC5127 - CAS 3056146-38-1

RMC5127 is an orally available, mutation-selective RAS G12V inhibitor exhibiting central nervous system (CNS) and brain permeability. It suppresses the RAS pathway and induces apoptosis in KRAS G12V mutant cancer cells, demonstrating antitumour activity.

Apoptosis, Kras, Ras, Kras

GPCR/G Protein, MAPK, Apoptosis

3056107

0.9754

C57H75N9O9S

1062.32

C[C@H](OC)C(N=C1)=[C@@]([C@@]2=C(CC(C)(C)COC([C@H]3NN(C([C@@H](NC([C@H]4OC[C@@H]4C)=O)[C@H]5N6CC7(COC7)C6)=O)C8CC3C8)=O)C9=C(C=CC(C%10=CSC5=N%10)=C9)N2CCOC%11CCOCC%11)C=C1N%12CCN(C%13CC%13)CC%12

-20°C

Ice Packs

Small Compound