RN-9893 (hydrochloride) - CAS 2109450-40-8

RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors) .1 It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively) . RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays) .

TRP/TRPV Channel, Others

Others, Membrane transporter/Ion channel

2109450-40-8

C21H24ClF3N4O5S

536.95

Cl.O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(C)C)C3=CC=C(C=C3N(=O)=O)C(F)(F)F

-20°C

Ice Packs

Small Compound