Ro 32-0432 hydrochloride - CAS 151342-35-7

Ro 32-0432 is a selective, ATP-competitive, orally active pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε. It blocks T-cell activation and may be employed in inflammatory and immune disorders. (S) -Ro 32-0432 hydrochloride is a GRK5 (G protein-coupled receptor kinase 5) inhibitor that alleviates nicotine withdrawal symptoms.

GRK, PKC

GPCR/G Protein, Chromatin/Epigenetic, Cytoskeletal Signaling

151300

C28H28N4O2

452.55

O=C1C(C2=C3N(C=4C2=CC=CC4)CC[C@H](CN(C)C)C3)=C(C(=O)N1)C=5C=6C(N(C)C5)=CC=CC6

-20°C

Ice Packs

Small Compound