RO1138452 - CAS 221529-58-4

RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3) . It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].

Prostaglandin Receptor

GPCR/G Protein, Immunology/Inflammation

221529-58-4

0.9934

C19H23N3O

309.41

CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1

-20°C

Ice Packs

Small Compound