RO314724 - CAS 112105-54-1

RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.

Others

Others

112050

C19H35N3O6

401.5

[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)(C(N[C@H](C(OCC)=O)C)=O)CC(C)C

-20°C

Ice Packs

Small Compound