Ro5-3335 - CAS 30195-30-3

Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM) . Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.

Others, DNA/RNA Synthesis

DNA Damage/DNA Repair, Others, Cell Cycle/Checkpoint

30195-30-3

0.9995

C13H10ClN3O

259.69

Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1

-20°C

Ice Packs

Small Compound