RO5461111 - CAS 1252637-46-9

RO5461111, a highly specific and orally active Cathepsin S antagonist, exhibits potent inhibitory effects with IC50 values of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. It effectively suppresses the activation of antigen-specific T cells and B cells, and can ameliorate pulmonary inflammation and lupus nephritis.

Others, Cysteine Protease

Others, Proteases/Proteasome

1252582

C27H24F6N4O4S

614.56

C(=O)(C1(C(F)(F)F)CC1)N2[C@H](C(NC3(C#N)CC3)=O)C[C@@H](S(=O)(=O)C4=C(C(F)(F)F)C=C(C=C4)C=5C=C(C)N=CC5)C2

-20°C

Ice Packs

Small Compound