ROCK-IN-9 - CAS 2643334-76-1

ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM. It demonstrates favorable pharmacokinetic properties in mice, achieving high in vivo exposure and oral bioavailability at low doses [1].

ROCK

Cytoskeletal Signaling, Stem Cells, Cell Cycle/Checkpoint

2643257

C20H20FN5O2

381.4

C(NCC1=CC(OC)=CC=C1)(=O)N2C=3C(=CC(=C(F)C3)C=4C(N)=NNC4)CC2

-20°C

Ice Packs

Small Compound