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Rolapitant hydrochloride - CAS 858102-79-1

Rolapitant hydrochloride - CAS 858102-79-1

MF-0013343-01

$186.01 USD
$186.01 USD
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Product Details

  • Bioactivity

    Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting, and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM, which does not interact with CYP3A4 and demonstrates potent centrally-mediated anti-emetic activity in both acute and delayed ferret emesis models [1] [2].

  • Target

    Neurokinin receptor

  • Related Pathways

    Neuroscience, GPCR/G Protein

  • CAS Number

    858022

  • Purity

    0.9979

  • Molecular Formula

    C25H27ClF6N2O2

  • Molecular Weight

    536.94

  • SMILES

    Cl.C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound