ROS-generating agent 1 - CAS 2369030-41-9

Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular TrxR protein levels and promotes ROs-dependent apoptosis and ferroptosis in NCI-H460 cells.

Reactive Oxygen Species, Ferroptosis, Apoptosis, ROS Kinase, ROS

Immunology/Inflammation, NF-κB, Tyrosine Kinase/Adaptors, Apoptosis, Metabolism

2368980

0.9976

C21H15F6NO

411.34

C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3

-20°C

Ice Packs

Small Compound