RP-6685 - CAS 2832047-80-8

RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].

DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2831959

0.9965

C22H14F7N5O

497.37

Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1

-20°C

Ice Packs

Small Compound