Rp-8-bromo-Cyclic AMPS (sodium salt) - CAS 925456-59-3

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.

Others, PKA

Others, Tyrosine Kinase/Adaptors

925394

C10H10BrN5NaO5PS

446.15

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=S)O[C@H]4[C@H]3O)c(Br)nc12

-20°C

Ice Packs

Small Compound