RP-832c - CAS 2375823-45-1

RP-832c is a synthetic analog of a host defense peptide (HDP) that targets the mannose receptor CD206 on M2-polarized macrophages with a Kd of 3.5 μM. Upon binding to CD206, RP-832c induces significant conformational changes in the receptor, activating signaling pathways that lead to rapid apoptosis of CD206-positive M2 macrophages and their repolarization to the M1 phenotype. Treatment with RP-832c significantly reduces CD206 gene expression in M2 macrophages and temporarily increases the expression of the M1 macrophage marker TNF-α. RP-832c is applicable for research on T-cell lymphomas (CTCL) and idiopathic pulmonary fibrosis (IPF) .

Apoptosis, TNF

Apoptosis

2375823-45-1

C68H94N20O11

1367.6

C([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@H](CCCNC(=N)N)N)=O)=O)CCCCN)=O)=O)=O)=O)=O)CCCCN)=O)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C=5C=6C(NC5)=CC=CC6

-20°C

Ice Packs

Peptide