RSL3 - CAS 1219810-16-8

RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM) . RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.

Glutathione Peroxidase, ROS, GPX, Reactive Oxygen Species, p62, Ferroptosis

Immunology/Inflammation, Oxidation-Reduction, Apoptosis, Metabolism, Autophagy, NF-κB

1219786

0.9996

C23H21ClN2O5

440.88

COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H](N1C(=O)CCl)c1ccc(cc1)C(=O)OC

-20°C

Ice Packs

Small Compound