RTx-152 - CAS 3035072-48-8

RTx-152 is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM) that targets Polθ captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

3035016

C20H16F7N3O3

479.35

O=C(OC=1C(=CC(=CC1C(F)(F)F)C(F)(F)F)N2C(=O)N(C)CC2)N(C3=CC=C(F)C=C3)C

-20°C

Ice Packs

Small Compound