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Molfinity

RU.521 - CAS 2262452-06-0

RU.521 - CAS 2262452-06-0

MF-0018129-01

$38.41 USD
$38.41 USD
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Product Details

  • Bioactivity

    RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 μM), (human: IC50=2.94 μM) . RU.521 is an inhibitor of the receptor activated by dsDNA (IC50=700 nM) . RU.521 inhibits cGAS-mediated interferon upregulation. RU.521 reduces constitutive interferon expression in macrophages derived from a mouse model of Aicardi-Goutieres syndrome.

  • Target

    DNA, cGAS

  • Related Pathways

    Immunology/Inflammation, DNA Damage/DNA Repair

  • CAS Number

    2262452-06-0

  • Purity

    0.9982

  • Molecular Formula

    C19H12Cl2N4O3

  • Molecular Weight

    415.23

  • SMILES

    Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound