Ruboxistaurin hydrochloride - CAS 169939-93-9

Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC) ; competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively) . Selective for PKCβ over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively) . Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src) .

PKC

Chromatin/Epigenetic, Cytoskeletal Signaling

169837

0.9928

C28H28N4O3·HCl

505.01

Cl.CN(C)CC1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21

-20°C

Ice Packs

Small Compound