RUNX1/ETO-IN-1 - CAS 923865-06-9

RUNX1/ETO-IN-1 is an inhibitor targeting the oncogenic fusion protein RUNX1-ETO, specifically affecting the NHR2 oligomerization domain. It binds directly to NHR2 (KD, app = 39 μM) . By inducing apoptosis and promoting differentiation, RUNX1/ETO-IN-1 exhibits antileukemic activity in RUNX1/ETO translocation acute myeloid leukemia (AML) cells. Its near-neutral charge under physiological pH conditions grants it excellent cell membrane permeability.

Apoptosis, Others

Others, Apoptosis

923865-06-9

C21H25N3O3S

399.51

O=C1C=C(N=C2SC=C(N12)C)CNC(C3=CC=C4OCCCOC4=C3)C(C)C

-20°C

Ice Packs

Small Compound