RUNX1/ETO tetramerization-IN-1 - CAS 88755-39-9

RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor targeting NHR2 of RUNX1/ETO, effectively inhibiting tetramerization with an EC50 value of 0.25 μM. This compound restores gene expression down-regulated by RUNX1/ETO and demonstrates anti-leukemic activity by inhibiting proliferation of RUNX1/ETO-dependent SKNO-1 cells and reducing tumor growth in a mouse model [1] [2] [3].

Others

Others

88707

C18H14O7

342.3

C(CC(=O)C=1C=C2C(=CC1)OCO2)(C(O)=O)C=3C=C4C(=CC3)OCO4

-20°C

Ice Packs

Small Compound