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RyR2 stabilizer-1 - CAS 3012675-16-7

RyR2 stabilizer-1 - CAS 3012675-16-7

MF-0115952-01

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Product Details

  • Bioactivity

    RyR2 stabilizer-1 (Compound12a) is a potent stabilizer of RyR2 and an activator of SERCA2a, with EC50 values of 2.7 μM for RyR2 and 383 nM for SERCA2. This compound inhibits the leakage of Ca2+ through SR RyR2 while promoting the reuptake of Ca2+ into the SR by SERCA2, suggesting its potential in preventing arrhythmias.

  • Target

    Calcium Channel

  • Related Pathways

    Membrane transporter/Ion channel, Metabolism

  • CAS Number

    3012652

  • Molecular Formula

    C28H46N2O3S

  • Molecular Weight

    490.74

  • SMILES

    OC1(CCCCN(CCCCN2CC3=CC(OC)=CC=C3SCC2)CCCCC4(O)CC4)CC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound