(S) -3'-amino Blebbistatin - CAS 2097141-18-7

" (S) -3'-amino Blebbistatin, retaining the active stereochemistry of the less stable and more phototoxic (–) -blebbistatin, serves as a refined selective cell-permeable inhibitor of non-muscle myosin II ATPases. This compound efficaciously inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across several species with IC50s ranging from 0.5-5 μM, and exhibits minimal inhibition against smooth muscle myosin (IC50= 80 μM) . Its primary functions include obstructing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. (S) -3'-amino Blebbistatin overcomes (–) -blebbistatin's limitation of rapid degradation under blue light (450-490 nm) exposure, which generates cytotoxic intermediates, thus posing a challenge for fluorescent live cell imaging applications. The introduction of a 3'-amino group to its structure notably reduces fluorescence while maintaining (–) -blebbistatin's activity, making it a superior alternative for research purposes."

Others, Myosin

Cytoskeletal Signaling, Others

2097141-18-7

C18H17N3O2

307.35

O[C@]12C(N(CC1)C3=CC(N)=CC=C3)=NC=4C(C2=O)=CC(C)=CC4

-20°C

Ice Packs

Small Compound