(S) -Afatinib - CAS 439081-18-2

(S) -Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.

P38 MAPK, Apoptosis, Akt, HER, c-Met/HGFR, EGFR, Autophagy

Cytoskeletal Signaling, Apoptosis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, MAPK, Autophagy

439061

>99.99%

C24H25ClFN5O3

485.94

CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1

-20°C

Ice Packs

Small Compound