(S) - (-) -Canadine - CAS 5096-57-1

(S) - (-) -Canadine (tetrahydroberberine) is a naturally occurring isoquinoline alkaloid, acting as a D2 receptor antagonist and 5-HT1A receptor agonist, capable of blocking dopamine-stimulated adenylate cyclase activity. (S) - (-) -Canadine also enhances gastrointestinal motility, blocks K (ATP) channels in substantia nigra pars compacta (SNc) dopaminergic neurons, and exerts neuroprotective effects.

ATPase, Dopamine Receptor, 5-HT Receptor

GPCR/G Protein, Membrane transporter/Ion channel, Neuroscience

5038

C20H21NO4

339.39

O(C)C1=C2CN3[C@](C=4C(=CC5=C(C4)OCO5)CC3)(CC2=CC=C1OC)[H]

-20°C

Ice Packs

Natural Product