(S) -dHTC1 - CAS 3081383-46-9

(S) -dHTC1 is a molecular glue degrader specifically targeting the transcriptional coactivator ENL. It exhibits high affinity binding to E3 ligase only upon formation of the ENL: (S) -dHTC1 complex, with an IC50 of 93 nM. In MV4;11 cells, (S) -dHTC1 degrades ENL with a DC50 of 26 nM. This compound can be utilized for acute myeloid leukemia research.

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PROTAC

3081328

C33H40N8O6S

676.786

O=C1[C@]2(CN(S(NC3CCN(CCNC(=O)C4=CC(=CC=C4)C5=CN6C(=N5)C=CC(C(NC7CCC7)=O)=C6)CC3)(=O)=O)CC2)CC(=O)N1

-20°C

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