(S) -DI-87 - CAS 2107280-58-8

(S) -DI-87 ((S) -TRE-515) is an isomer of DI-87.DI-87 is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding.DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, resulting in a reduction in dNTP production and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.

DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2107214

0.9942

C23H30N6O3S2

502.65

[C@H](SC=1N=C(N)C=C(N)N1)(C)C=2N=C(SC2C)C3=CC(OCCN4CCOCC4)=C(OC)C=C3

-20°C

Ice Packs

Small Compound