S- (N-Methylsulfinylbutylthiocarbamoyl) -L-cysteine - CAS 364083-21-6

S- (N-Methylsulfinylbutylthiocarbamoyl) -L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 μM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 μM, it significantly lowers the expression of α-tubulin, βIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T) . Additionally, when used at 30 μM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.

Others, Drug Metabolite

Others, Metabolism

364083-21-6

C9H18N2O3S3

298.45

O=C(O)[C@@H](N)CSC(NCCCCS(C)=O)=S

-20°C

Ice Packs

Small Compound