(S, R, S) -AHPC-C2-amide-benzofuranylmethyl-pyridine - CAS 2347517-69-3

(S, R, S) -AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-target PROTAC capable of directing ubiquitination and degradation of Smad3 while also elevating HIF-α protein levels, exhibiting multipath anti-fibrotic and renal protective functions, making it valuable for renal anemia research [1].

HIF/HIF Prolyl-Hydroxylase, PROTACs, TGF-beta/Smad

Chromatin/Epigenetic, Metabolism, PROTAC, Stem Cells

2347445

C41H46N6O6S

750.91

C(NC(CCC(N[C@H](C(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)C(C)(C)C)=O)=O)(C4=CC=5C(O4)=CC=CC5)C=6C=CC=NC6

-20°C

Ice Packs

PROTAC