(S, R, S) -AHPC-Me hydrochloride - CAS 1948273-03-7

(S, R, S) -AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is utilized in the synthesis of ARV-771, a potent BET protein degrader. It selectively degrades BET protein in castration-resistant cells with a DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, it serves as the VHL ligand from (S, R, S) -AHPC for recruiting von Hippel-Lindau (VHL) protein.

Ligand for E3 Ligase

PROTAC

1948273-03-7

0.9918

C23H33ClN4O3S

481.05

Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C

-20°C

Ice Packs

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