(S, R, S) -AHPC-PEG2-NHS ester - CAS 2757045-58-0

(S, R, S) -AHPC-PEG2-NHS ester is a synthetic PROTAC linker that combines the E3 ligase ligand with a PEG linker to enhance PROTAC pharmacology. The NHS ester reacts with amine groups, and the hydrophilic PEG spacer increases water solubility.

PROTAC Linker

PROTAC

2756987

C34H45N5O10S

715.814

C(C(NC(CCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)C(C)(C)C)(=O)N2[C@H](C(NCC3=CC=C(C=C3)C=4SC=NC4C)=O)C[C@@H](O)C2

-20°C

Ice Packs

PROTAC