(S, R, S) -AHPC TFA - CAS 1631137-51-3

(S, R, S) -AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 μM in Ba/F3 cells.

Ligand for E3 Ligase

PROTAC

1631083

0.9799

C24H31F3N4O5S

544.59

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3.O=C(O)C(F)(F)F

-20°C

Ice Packs

PROTAC