(S) -Ro 32-0432 - CAS 1781828-85-0

(S) -Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S) -Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].

Others, PKC

Others, Chromatin/Epigenetic, Cytoskeletal Signaling

1781828-85-0

C28H29ClN4O2

489.01

O=C1C(C2=C3N(C=4C2=CC=CC4)CC[C@H](CN(C)C)C3)=C(C(=O)N1)C=5C=6C(N(C)C5)=CC=CC6.Cl

-20°C

Ice Packs

Small Compound