(S) -WSD0628 - CAS 2765449-10-1

(S) -WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.

ATM/ATR

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

2765438

C23H23F2N5O2

439.458

O=C1N(C=2C=3C(N=CC2N1C)=CC=C(C3)C=4C=CC(OC)=NC4)[C@@H]5C(F)(F)CN(C)CC5

-20°C

Ice Packs

Small Compound