S118 - CAS 2677041-36-8

S118 is an orally active inhibitor of the sphingosine-1-phosphate receptor 2 (S1P2 receptor) . It prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin, and blocks the nuclear translocation of the S1P2 receptor. This process inhibits inflammation, fibrosis, and epithelial-mesenchymal transition (EMT), thereby exhibiting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is considered promising for research in idiopathic pulmonary fibrosis.

Wnt/beta-catenin

Stem Cells, Cytoskeletal Signaling

2676997

C19H14Cl2FN7O

446.265

O=C(NNC=1N=C2C(C=NN2C)=C(C1)C=3C=CC(F)=CC3)NC=4C=C(Cl)N=C(Cl)C4

-20°C

Ice Packs

Small Compound