S39625 - CAS 536711-20-3

S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate.

Others, Topoisomerase

DNA Damage/DNA Repair, Others

536688

C25H22N2O5

430.45

O=C1N2CC=3C(C2=CC4=C1CC(=O)C4(CC)O)=NC=5C(C3C6CCC6)=CC7=C(C5)OCO7

-20°C

Ice Packs

Small Compound