Safusidenib - CAS 1898206-17-1

Safusidenib is a selective, orally active mutant inhibitor of IDH1 that significantly inhibits mutant IDH1, but not wild-type IDH1, and inhibits tumor activity in chondrosarcoma. safusidenib is active against IDH1R132H and IDH1R132C, and in the absence of preincubation, the IC50 values were 15 and 130 nM, respectively.

Others, Isocitrate Dehydrogenase (IDH)

Others, Metabolism

1898188

C25H18Cl3FN2O4

535.78

C(=O)(C=1C(=NOC1C(C)(C)F)C2=C(Cl)C=C(Cl)C=C2Cl)N3C=4C(C(C)=C3)=C(/C=C/C(O)=O)C=CC4

-20°C

Ice Packs

Small Compound