SAH-EZH2 - CAS 1453222-26-8

EZH2/EPP interaction inhibitor (Kd = 320 nM) . Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.

Histone Methyltransferase

Chromatin/Epigenetic

1453188

C155H256N48O40

3432.05

C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@]1(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CCCCN)NC(=O)[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C)=O)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(=N)N)=O)(C)CCCC=CCCC1)[H])CCCNC(=N)N)=O)[C@@H](C)O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(N)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)CCC3)CCC(N)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCCN)=O)C=4C=5C(NC4)=CC=CC5

-20°C

Ice Packs

Peptide