Saikogenin D - CAS 5573-16-0

Saikogenin D possesses dual mechanisms of action including inhibition of A23187-induced PGE2 production without direct cyclooxygenase suppression, and stimulation of intracellular calcium elevation through Ca2+ release from internal stores, while further displaying immunomodulatory properties demonstrated by its ability to attenuate IL-6 production in LPS-stimulated alveolar macrophages from B6 mice more strongly than in BALB mice, highlighting selective regulation of inflammatory responses.

Prostaglandin Receptor, Potassium Channel, IL Receptor, Calcium Channel

GPCR/G Protein, Metabolism, Membrane transporter/Ion channel, Immunology/Inflammation

5557

0.9999

C30H48O4

472.7

C[C@]12[C@@]3(C)C(=C4[C@@](CO)([C@H](O)C3)CCC(C)(C)C4)C=C[C@@]1([C@]5(C)[C@@](CC2)([C@@](CO)(C)[C@@H](O)CC5)[H])[H]

-20°C

Ice Packs

Natural Product