Salvinorin A Propionate - CAS 689295-71-4

Salvinorin A propionate is a selective partial agonist at κ1-opioid receptors (KOR) with a Ki value of 32.6 nM. It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR. It is selective for KORs over μ, δ, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 μg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A .

Others, Opioid Receptor

Others, Endocrinology/Hormones, Neuroscience, GPCR/G Protein

689220

C24H30O8

446.49

C[C@@]12[C@@]3([C@](C)([C@H](C(OC)=O)C[C@H](OC(CC)=O)C3=O)CC[C@]1(C(=O)O[C@@H](C2)C=4C=COC4)[H])[H]

-20°C

Ice Packs

Small Compound