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Molfinity

Sapitinib - CAS 848942-61-0

Sapitinib - CAS 848942-61-0

MF-0014850-01

$33.92 USD
$33.92 USD
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Product Details

  • Bioactivity

    Sapitinib (AZD-8931), a reversible, ATP competitive inhibitor of EGFR (IC50=4 nM), ErbB2 (IC50=3 nM) and ErbB3 (IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the ErbB family over MNK1 and Flt.

  • Target

    EGFR

  • Related Pathways

    JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

  • CAS Number

    848881

  • Purity

    0.9983

  • Molecular Formula

    C23H25ClFN5O3

  • Molecular Weight

    473.93

  • SMILES

    CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound