SARM1-IN-4 - CAS 3069378-18-0

SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.

TLR

Immunology/Inflammation

3069360

C13H17F2N3O2

285.29

N(C(N([C@@H](C)C=1C=CN=CC1)C)=O)[C@H]2C(F)(F)COC2

-20°C

Ice Packs

Small Compound