SARS-CoV-2-IN-115 - CAS 2557232-80-9

SARS-CoV-2-IN-115 (Compound 3e) is a potent inhibitor of SARS-CoV-2, showing strong antiviral activity in infected Calu-3 cells with an EC50 of 1.7 μM. It effectively inhibits human dihydroorotate dehydrogenase (HsDHODH) activity with an IC50 of 1.5 μM. Importantly, SARS-CoV-2-IN-115 maintains immune response without affecting the proliferation of CD4 T cells.

Dehydrogenase, DNA/RNA Synthesis, SARS-CoV

Microbiology/Virology, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism

2557143

C16H14N2O

250.3

O=C(NC1=CC=C(C#CC2=CC=CC(N)=C2)C=C1)C

-20°C

Ice Packs

Small Compound