SARS-CoV-IN-6 - CAS 2244671-47-2

SARS-CoV-IN-6 (Compound 17) acts as an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, demonstrating an IC50 value of 7.8 μM against SARS-CoV-2 RdRp. This compound reduces the cytopathic effects of single-round infectious particles (SRIP) infected with SARS-CoV-1 and SARS-CoV-2 replicons and inhibits the expression of SARS-CoVN proteins. The EC50 values for SRIP based on SARS-CoV-1 and SARS-CoV-2 replicons are 0.12 μM and 1.47 μM, respectively.

SARS-CoV

Microbiology/Virology

2244622

C25H29N5O3

447.53

C(N1C[C@@]2(C=3N(C[C@@](C2)(C1)[H])C(=O)C(NCC=4C(=O)N(C)C(=O)N(C)C4)=CC3)[H])C5=CC=CC=C5

-20°C

Ice Packs

Small Compound