SAX-187 hydrochloride - CAS 554403-08-6

SAX-187 hydrochloride is a potent and selective 5-HT6 receptor agonist. SAX-187 hydrochloride possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (SAX-187 hydrochloride: EC50=6.6 nM, Emax=93%) . In the rat frontal cortex, acute administration of SAX-187 hydrochloride (3-30 mg/kg, subcutaneous (s.c.) ) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

5-HT Receptor, Others

Others, Neuroscience, GPCR/G Protein

554403-08-6

C15H14Cl2N4O2S2

417.33

S(=O)(=O)(N1C=2C(C(CCN)=C1)=CC=CC2)C=3N4C(=NC3Cl)SC=C4.Cl

-20°C

Ice Packs

Small Compound