SB 203580 hydrochloride - CAS 869185-85-3

SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38β2, LCK, GSK3β, and PKBα. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain.

Mitophagy, Autophagy, p38 MAPK, Src

MAPK, Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors

869185-85-3

0.9779

C21H17ClFN3OS

413.9

Cl.O=S(C=1C=CC(=CC1)C2=NC(C=3C=CN=CC3)=C(N2)C=4C=CC(F)=CC4)C

-20°C

Ice Packs

Small Compound