SB-277011 hydrochloride - CAS 215804-67-4

SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, and orally active dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier, with Ki values of 10.7 nM for rodent D3R and 11.2 nM for human D3R. It is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi: 8.0), D2 receptors (pKi: 6.0), 5-HT1B receptors (pKi < 5.2), and 5-HT1D receptors (pKi: 5.9) .

5-HT Receptor, Dopamine Receptor

Neuroscience, GPCR/G Protein

215733

0.9854

C28H31ClN4O

475.03

C(N[C@@H]1CC[C@@H](CCN2CC=3C(CC2)=CC(C#N)=CC3)CC1)(=O)C=4C5=C(N=CC4)C=CC=C5.Cl

-20°C

Ice Packs

Small Compound