SB-284851-BT - CAS 219769-23-0

SB-284851-BT is a chemical compound that serves as an inhibitor of BRD4, p38α, and BRDT, exhibiting varying degrees of affinity and inhibition for each. Specifically, it inhibits BRD4-BD1 with an IC50 value of 1.7 μM, p38α with a Kd of 0.47 nM, BRDT (1) with an IC50 value of 18 μM, and BRD4 (1) with an IC50 value of 3.7 μM. By targeting p38α, SB-284851-BT effectively reduces IL-8 production and, through inhibiting BRD4, down-regulates both the c-Myc and NF-κB gene pathways, crucial in cancer pathways. Additionally, SB-284851-BT is designed to combine with the bromine domain and extra terminal (BET) proteins.

P38 MAPK, Epigenetic Reader Domain, Others

Others, MAPK, Chromatin/Epigenetic

219746

C26H26FN5O

443.52

O(C=1N=C(C2=C(N=CN2C3CCNCC3)C4=CC=C(F)C=C4)C=CN1)C5=CC(C)=CC(C)=C5

-20°C

Ice Packs

Small Compound