SB-505124 hydrochloride - CAS 356559-13-2

SB-505124 hydrochloride (SB505124 hydrochloride) is an orally available, selective and potent inhibitor of TGF-β type I receptors (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. SB-505124 hydrochloride inhibits IL-6 production by synovial explants and reduces Th17 differentiation in mice by decreasing Il17a and Rorc gene expression and IL-17 protein production.SB-505124 hydrochloride is used in the study of colorectal cancer.

ALK, TGF-beta/Smad

Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells

356544

0.9871

C20H22ClN3O2

371.86

Cl.N=1C(=CC=CC1C)C=2N=C(NC2C=3C=CC=4OCOC4C3)C(C)(C)C

-20°C

Ice Packs

Small Compound