SB-612111 - CAS 371980-98-2

SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki = 0.33 nM) . It exhibits selectivity for μ-, κ-, and δ-receptors with Ki values of 57.6 nM, 160.5 nM, and 2109 nM, respectively. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].

Opioid Receptor, Others

Neuroscience, Endocrinology/Hormones, GPCR/G Protein, Others

371880

C24H29Cl2NO

418.4

ClC1=C(C2CCN(C[C@@H]3C[C@H](O)C=4C(CC3)=C(C)C=CC4)CC2)C(Cl)=CC=C1

-20°C

Ice Packs

Small Compound