SB-T-101141 - CAS 186348-05-0

SB-T-101141 is a novel taxane drug effective in inducing atypical ferroptosis, thereby overcoming resistance of breast cancer to Paclitaxel. It promotes the generation of iron ions, ferrous ions, and reactive oxygen species (ROS) . SB-T-101141 stably binds to KHSRP, inhibiting the expression of the iron-dependent CISD1 related to iron homeostasis. It synergistically enhances the activation of the iron-dependent JNK and PERK pathways through KHSRP. SB-T-101141 inhibits breast tumor growth in MCF-7 (PR) /MDA-MB-231 (PR) or KHSRP knockout MCF-7 xenograft mouse models.

JNK, Ferroptosis, p38 MAPK, ROS, PERK

MAPK, Immunology/Inflammation, Apoptosis

186348-05-0

C44H55NO17

869.9

O(C(=O)C1=CC=CC=C1)[C@@H]2[C@]34[C@]([C@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C=C(C)C)O)=O)C(C)=C(C3(C)C)[C@@H](OC(C)=O)C(=O)[C@@]5(C)[C@]2([C@@]6(OC(C)=O)[C@](OC6)(C[C@@H]5O)[H])[H])(OC(=O)O4)[H]

-20°C

Ice Packs

Small Compound